Dr. Wethe is the Co-Director and lead neuropsychologist for the Mayo Clinic Arizona Concussion Program. She has more than 15 years of experience in the assessment and rehabilitation of adults and children with acquired brain injury and other neurological conditions. Prior to joining Mayo Clinic in 2013, Dr. Wethe oversaw and coordinated the rehabilitation of patients with acquired brain injury at Hook Rehabilitation's comprehensive adult outpatient neurorehabilitation program at Community Health Network in Indianapolis, Indiana. Prior to that she was at Barrow Neurological Institute / St. Joseph's Hospital and Medical Center in Phoenix, Arizona, where she was an Associate Professor of Neuropsychology and Associate Director of the Children's Center for Neuropsychological Rehabilitation. She was instrumental in the development of the interdisciplinary B.R.A.I.N.S. (concussion) Clinic.

Dr. Wethe's research interests include factors that influence concussion and rehabilitation outcome, chronic traumatic encephalopathy (CTE), clinical test validation, and neurobehavioral functioning in patients with hypothalamic hamartoma. Since joining the Mayo Clinic, Dr. Wethe has been the Principal Investigator for the multi-organization Correlates of Youth Athletic Participation study and the Emerging Tools in the Evaluation and Management of Concussion study. She was awarded the Penske Career Development Award for Research at Mayo Clinic Arizona for expanding the Correlates of Youth Athletic Participation study to include comprehensive longitudinal follow-up of concussed athletes and matched controls. She is also co-investigator on a large, longitudinal NIH/NINH grant to study CTE in retired professional athletes and controls.